diff --git a/sys/include/net/gnrc/dhcpv6/client/6lbr.h b/sys/include/net/gnrc/dhcpv6/client/6lbr.h
index f622d236ab..c35cfd484c 100644
--- a/sys/include/net/gnrc/dhcpv6/client/6lbr.h
+++ b/sys/include/net/gnrc/dhcpv6/client/6lbr.h
@@ -34,6 +34,18 @@ extern "C" {
 #define CONFIG_GNRC_DHCPV6_CLIENT_6LBR_UPSTREAM     (0)
 #endif
 
+/**
+ * @brief   6LoWPAN compression context lifetime for configured prefixes in
+ *          minutes
+ *
+ * Must be between 1 and 255
+ *
+ * @see     [RFC 6775, section 4.2](https://tools.ietf.org/html/rfc6775#section-4.2)
+ */
+#ifndef CONFIG_GNRC_DHCPV6_CLIENT_6LBR_6LO_CTX_MIN
+#define CONFIG_GNRC_DHCPV6_CLIENT_6LBR_6LO_CTX_MIN  (60U)
+#endif
+
 /**
  * @brief   Use static routes to upstream router
  *
diff --git a/sys/net/gnrc/application_layer/dhcpv6/Kconfig b/sys/net/gnrc/application_layer/dhcpv6/Kconfig
index 2b55f9dc11..c6b15a0916 100644
--- a/sys/net/gnrc/application_layer/dhcpv6/Kconfig
+++ b/sys/net/gnrc/application_layer/dhcpv6/Kconfig
@@ -13,6 +13,14 @@ config GNRC_DHCPV6_CLIENT_6LBR_UPSTREAM
     help
         Leave 0 to let the client pick the first non-6LoWPAN interface it finds
 
+config GNRC_DHCPV6_CLIENT_6LBR_6LO_CTX_MIN
+    int "6LoWPAN compression context lifetime for configured prefixes in minutes"
+    default 60
+    range 1 255
+    help
+        @see [RFC 6775, section 4.2](https://tools.ietf.org/html/rfc6775#section-4.2)
+
+
 config GNRC_DHCPV6_CLIENT_6LBR_STATIC_ROUTE
     bool "Use static routes to upstream interface"
     help
diff --git a/sys/net/gnrc/application_layer/dhcpv6/client.c b/sys/net/gnrc/application_layer/dhcpv6/client.c
index b8443d1796..c0014b1981 100644
--- a/sys/net/gnrc/application_layer/dhcpv6/client.c
+++ b/sys/net/gnrc/application_layer/dhcpv6/client.c
@@ -16,7 +16,9 @@
 #include "log.h"
 #include "net/arp.h"
 #include "net/dhcpv6.h"
+#include "net/gnrc/dhcpv6/client/6lbr.h"
 #include "net/gnrc/ipv6/nib/pl.h"
+#include "net/gnrc/sixlowpan/ctx.h"
 #include "net/gnrc/netif.h"
 #include "net/gnrc/rpl.h"
 #include "net/sock.h"
@@ -70,6 +72,44 @@ unsigned dhcpv6_client_get_duid_l2(unsigned iface, dhcpv6_duid_l2_t *duid)
     return (uint8_t)res + sizeof(dhcpv6_duid_l2_t);
 }
 
+static bool _ctx_match(const gnrc_sixlowpan_ctx_t *ctx,
+                       const ipv6_addr_t *prefix, uint8_t prefix_len)
+{
+    return (ctx != NULL) &&
+           (ctx->prefix_len == prefix_len) &&
+           (ipv6_addr_match_prefix(&ctx->prefix, prefix) >= prefix_len);
+}
+
+static void _update_6ctx(const ipv6_addr_t *prefix, uint8_t prefix_len)
+{
+    gnrc_sixlowpan_ctx_t *ctx = gnrc_sixlowpan_ctx_lookup_addr(prefix);
+    uint8_t cid = 0;
+
+    if (!_ctx_match(ctx, prefix, prefix_len)) {
+        /* While the context is a prefix match, the defined prefix within the
+         * context does not match => use new context */
+        ctx = NULL;
+    }
+    else {
+        cid = ctx->flags_id & GNRC_SIXLOWPAN_CTX_FLAGS_CID_MASK;
+    }
+    /* find first free context ID */
+    if (ctx == NULL) {
+        while (((ctx = gnrc_sixlowpan_ctx_lookup_id(cid)) != NULL) &&
+               !_ctx_match(ctx, prefix, prefix_len)) {
+            cid++;
+        }
+    }
+    if (cid < GNRC_SIXLOWPAN_CTX_SIZE) {
+        DEBUG("DHCP client: add compression context %u for prefix %s/%u\n", cid,
+              ipv6_addr_to_str(addr_str, prefix, sizeof(addr_str)),
+              prefix_len);
+        gnrc_sixlowpan_ctx_update(cid, (ipv6_addr_t *)prefix, prefix_len,
+                                  CONFIG_GNRC_DHCPV6_CLIENT_6LBR_6LO_CTX_MIN,
+                                  true);
+    }
+}
+
 void dhcpv6_client_conf_prefix(unsigned iface, const ipv6_addr_t *pfx,
                                unsigned pfx_len, uint32_t valid,
                                uint32_t pref)
@@ -110,6 +150,9 @@ void dhcpv6_client_conf_prefix(unsigned iface, const ipv6_addr_t *pfx,
         if (IS_USED(MODULE_GNRC_IPV6_NIB) &&
             GNRC_IPV6_NIB_CONF_6LBR &&
             GNRC_IPV6_NIB_CONF_MULTIHOP_P6C) {
+            if (IS_USED(MODULE_GNRC_SIXLOWPAN_CTX)) {
+                _update_6ctx(pfx, pfx_len);
+            }
             (void)gnrc_ipv6_nib_abr_add(&addr);
         }
         if (IS_USED(MODULE_GNRC_RPL)) {