diff --git a/sys/usb/usbus/dfu/dfu.c b/sys/usb/usbus/dfu/dfu.c
index b838978d24..d2ab4f9652 100644
--- a/sys/usb/usbus/dfu/dfu.c
+++ b/sys/usb/usbus/dfu/dfu.c
@@ -101,7 +101,17 @@ void usbus_dfu_init(usbus_t *usbus, usbus_dfu_device_t *handler, unsigned mode)
     DEBUG("DFU: initialization\n");
     assert(usbus);
     assert(handler);
-    assert((SLOT0_OFFSET % FLASHPAGE_SIZE) == 0);
+#if defined(FLASHPAGE_SIZE)
+    static_assert((SLOT0_OFFSET % FLASHPAGE_SIZE) == 0,
+                  "SLOT0_OFFSET has to be a multiple of FLASHPAGE_SIZE");
+#elif defined(FLASHPAGE_MIN_SECTOR_SIZE)
+    /* STM32F2/4/7 MCUs use sectors instead of pages, where the minimum sector
+     * size is defined by FLASHPAGE_MIN_SECTOR_SIZE, which is 16KB or 32KB
+     * (the first sector) depending on the CPU_MODEL. In this case SLOT0_OFFSET
+     * must be a multiple of the minimum sector size to cover a whole sector. */
+    static_assert((SLOT0_OFFSET % FLASHPAGE_MIN_SECTOR_SIZE) == 0,
+                  "SLOT0_OFFSET has to be a multiple of FLASHPAGE_MIN_SECTOR_SIZE");
+#endif
     memset(handler, 0, sizeof(usbus_dfu_device_t));
     handler->usbus = usbus;
     handler->handler_ctrl.driver = &dfu_driver;