diff --git a/cpu/sam0_common/periph/flashpage.c b/cpu/sam0_common/periph/flashpage.c
index 3481229870..ba49aa3d1d 100644
--- a/cpu/sam0_common/periph/flashpage.c
+++ b/cpu/sam0_common/periph/flashpage.c
@@ -73,7 +73,12 @@ static unsigned _unlock(void)
     PAC1->WPCLR.reg = PAC1_WPROT_DEFAULT_VAL;
 #endif
 
+    /* NVM reads could be corrupted when mixing NVM reads with Page Buffer writes. */
     return irq_disable();
+#ifdef NVMCTRL_CTRLA_CACHEDIS1
+    _NVMCTRL->CTRLA.reg |= NVMCTRL_CTRLA_CACHEDIS0
+                        |  NVMCTRL_CTRLA_CACHEDIS1;
+#endif
 }
 
 static void _lock(unsigned state)
@@ -87,6 +92,11 @@ static void _lock(unsigned state)
     PAC1->WPSET.reg = PAC1_WPROT_DEFAULT_VAL;
 #endif
 
+#ifdef NVMCTRL_CTRLA_CACHEDIS1
+    _NVMCTRL->CTRLA.reg &= ~NVMCTRL_CTRLA_CACHEDIS0
+                        &  ~NVMCTRL_CTRLA_CACHEDIS1;
+#endif
+
     /* cached flash contents may have changed - invalidate cache */
 #ifdef CMCC
     CMCC->MAINT0.reg |= CMCC_MAINT0_INVALL;