diff --git a/cpu/stm32_common/periph/i2c_2.c b/cpu/stm32_common/periph/i2c_2.c
index b18ac8bd7d..5a68a0167e 100644
--- a/cpu/stm32_common/periph/i2c_2.c
+++ b/cpu/stm32_common/periph/i2c_2.c
@@ -218,8 +218,13 @@ int i2c_read_bytes(i2c_t dev, uint16_t address, void *data, size_t length,
     I2C_TypeDef *i2c = i2c_config[dev].dev;
     DEBUG("[i2c] read_bytes: Starting\n");
 
-    /* Do not support repeated start reading */
-    if ((i2c->SR2 & I2C_SR2_BUSY) && !(flags & I2C_NOSTART)) {
+    /* Do not support repeated start reading
+     * The repeated start read requires the bus to be busy (I2C_SR2_BUSY == 1)
+     * the previous R/W state to be a read (I2C_SR2_TRA == 0)
+     * and for the command not to be split frame (I2C_NOSTART == 0)
+    */
+    if (((i2c->SR2 & (I2C_SR2_BUSY | I2C_SR2_TRA)) == I2C_SR2_BUSY) &&
+        !(flags & I2C_NOSTART)) {
         return -EOPNOTSUPP;
     }
     int ret = _start(i2c, (address << 1) | I2C_FLAG_READ, flags, length);