diff --git a/pkg/semtech-loramac/Makefile.dep b/pkg/semtech-loramac/Makefile.dep
index 84d9dbab21..1bd02cfb96 100644
--- a/pkg/semtech-loramac/Makefile.dep
+++ b/pkg/semtech-loramac/Makefile.dep
@@ -6,6 +6,9 @@ USEMODULE += semtech_loramac_mac_region
 USEMODULE += semtech_loramac_crypto
 USEMODULE += semtech_loramac_arch
 
+USEMODULE += ztimer_msec
+USEMODULE += ztimer_periph_rtt
+
 # The build fails on MSP430 because the toolchain doesn't provide
 # EXIT_SUCCESS/EXIT_FAILURE macros
 FEATURES_BLACKLIST += arch_msp430
diff --git a/pkg/semtech-loramac/contrib/semtech_loramac_radio.c b/pkg/semtech-loramac/contrib/semtech_loramac_radio.c
index a0cf9be655..e37bb6f9ee 100644
--- a/pkg/semtech-loramac/contrib/semtech_loramac_radio.c
+++ b/pkg/semtech-loramac/contrib/semtech_loramac_radio.c
@@ -122,7 +122,7 @@ void SX127XSetTxConfig(RadioModems_t modem, int8_t power, uint32_t fdev,
     sx127x_set_tx_power(&sx127x, power);
     sx127x_set_preamble_length(&sx127x, preambleLen);
     sx127x_set_rx_single(&sx127x, false);
-    sx127x_set_tx_timeout(&sx127x, timeout * US_PER_MS); /* base unit us, LoRaMAC ms */
+    sx127x_set_tx_timeout(&sx127x, timeout); /* base unit ms, LoRaMAC ms */
 }
 
 uint32_t SX127XTimeOnAir(RadioModems_t modem, uint8_t pktLen)
@@ -153,7 +153,7 @@ void SX127XStandby(void)
 
 void SX127XRx(uint32_t timeout)
 {
-    sx127x_set_rx_timeout(&sx127x, timeout * US_PER_MS);
+    sx127x_set_rx_timeout(&sx127x, timeout);
     sx127x_set_rx(&sx127x);
 }
 
diff --git a/pkg/semtech-loramac/contrib/semtech_loramac_timer.c b/pkg/semtech-loramac/contrib/semtech_loramac_timer.c
index d1ed507407..3a04e5a737 100644
--- a/pkg/semtech-loramac/contrib/semtech_loramac_timer.c
+++ b/pkg/semtech-loramac/contrib/semtech_loramac_timer.c
@@ -19,7 +19,7 @@
  * @}
  */
 
-#include "xtimer.h"
+#include "ztimer.h"
 #include "thread.h"
 #include "semtech-loramac/timer.h"
 
@@ -27,7 +27,14 @@ extern kernel_pid_t semtech_loramac_pid;
 
 void TimerInit(TimerEvent_t *obj, void (*cb)(void))
 {
-    obj->dev = (xtimer_t) { 0 };
+    obj->dev = (ztimer_t) {
+        .base = {
+            .next =  NULL,
+            .offset = 0,
+        },
+        .callback = NULL,
+        .arg = NULL,
+    };
     obj->running = 0;
     obj->cb = cb;
 }
@@ -41,43 +48,43 @@ void TimerReset(TimerEvent_t *obj)
 void TimerStart(TimerEvent_t *obj)
 {
     obj->running = 1;
-    xtimer_t *timer = &(obj->dev);
+    ztimer_t *timer = &(obj->dev);
     msg_t *msg = &(obj->msg);
     msg->type = MSG_TYPE_MAC_TIMEOUT;
     msg->content.value = (uintptr_t)obj->cb;
-    xtimer_set_msg(timer, obj->timeout, msg, semtech_loramac_pid);
+    ztimer_set_msg(ZTIMER_MSEC, timer, obj->timeout, msg, semtech_loramac_pid);
 }
 
 void TimerStop(TimerEvent_t *obj)
 {
     obj->running = 0;
-    xtimer_remove(&(obj->dev));
+    ztimer_remove(ZTIMER_MSEC, &(obj->dev));
 }
 
 void TimerSetValue(TimerEvent_t *obj, uint32_t value)
 {
     if (obj->running) {
-        xtimer_remove(&(obj->dev));
+        ztimer_remove(ZTIMER_MSEC, &(obj->dev));
     }
 
-    obj->timeout = value * US_PER_MS;
+    obj->timeout = value;
 }
 
 TimerTime_t TimerGetCurrentTime(void)
 {
-    uint64_t CurrentTime = xtimer_now_usec64() / US_PER_MS;
+    uint64_t CurrentTime = ztimer_now(ZTIMER_MSEC);
     return (TimerTime_t)CurrentTime;
 }
 
 TimerTime_t TimerGetElapsedTime(TimerTime_t savedTime)
 {
-    uint64_t CurrentTime = xtimer_now_usec64() / US_PER_MS;
+    uint64_t CurrentTime = ztimer_now(ZTIMER_MSEC);
     return (TimerTime_t)(CurrentTime - savedTime);
 }
 
 TimerTime_t TimerGetFutureTime(TimerTime_t eventInFuture)
 {
-    uint64_t CurrentTime = xtimer_now_usec64() / US_PER_MS;
+    uint64_t CurrentTime = ztimer_now(ZTIMER_MSEC);
     return (TimerTime_t)(CurrentTime + eventInFuture);
 }
 
diff --git a/pkg/semtech-loramac/include/semtech-loramac/timer.h b/pkg/semtech-loramac/include/semtech-loramac/timer.h
index cce20f2083..54e01a4380 100644
--- a/pkg/semtech-loramac/include/semtech-loramac/timer.h
+++ b/pkg/semtech-loramac/include/semtech-loramac/timer.h
@@ -26,7 +26,7 @@
 extern "C" {
 #endif
 
-#include "xtimer.h"
+#include "ztimer.h"
 #include "msg.h"
 
 #include "semtech_loramac.h"
@@ -37,7 +37,7 @@ extern "C" {
 typedef struct TimerEvent_s {
     uint32_t timeout;   /**< Timer timeout in us */
     uint8_t running;    /**< Check if timer is running */
-    xtimer_t dev;       /**< xtimer instance attached to this LoRaMAC timer */
+    ztimer_t dev;       /**< ztimer instance attached to this LoRaMAC timer */
     msg_t msg;          /**< message attacher to this LoRaMAC timer */
     void (*cb)(void);   /**< callback to call when timer timeout */
 } TimerEvent_t;