diff --git a/cpu/sam0_common/include/periph_cpu_common.h b/cpu/sam0_common/include/periph_cpu_common.h
index 495a031399..2dd5839aad 100644
--- a/cpu/sam0_common/include/periph_cpu_common.h
+++ b/cpu/sam0_common/include/periph_cpu_common.h
@@ -168,6 +168,8 @@ typedef enum {
     UART_FLAG_NONE            = 0x0,    /**< No flags set */
     UART_FLAG_RUN_STANDBY     = 0x1,    /**< run SERCOM in standby mode */
     UART_FLAG_WAKEUP          = 0x2,    /**< wake from sleep on receive */
+    UART_FLAG_RXINV           = 0x4,    /**< invert RX signal */
+    UART_FLAG_TXINV           = 0x8,    /**< invert TX signal */
 } uart_flag_t;
 
 #ifndef DOXYGEN
diff --git a/cpu/sam0_common/periph/uart.c b/cpu/sam0_common/periph/uart.c
index 41ebccec1d..366edbae9e 100644
--- a/cpu/sam0_common/periph/uart.c
+++ b/cpu/sam0_common/periph/uart.c
@@ -114,6 +114,18 @@ int uart_init(uart_t uart, uint32_t baudrate, uart_rx_cb_t rx_cb, void *arg)
     if (uart_config[uart].flags & UART_FLAG_RUN_STANDBY) {
         dev(uart)->CTRLA.reg |= SERCOM_USART_CTRLA_RUNSTDBY;
     }
+#ifdef SERCOM_USART_CTRLA_RXINV
+    /* COM100-61: The TXINV and RXINV bits in the CTRLA register have inverted functionality. */
+    if (uart_config[uart].flags & UART_FLAG_TXINV) {
+        dev(uart)->CTRLA.reg |= SERCOM_USART_CTRLA_RXINV;
+    }
+#endif
+#ifdef SERCOM_USART_CTRLA_TXINV
+    /* COM100-61: The TXINV and RXINV bits in the CTRLA register have inverted functionality. */
+    if (uart_config[uart].flags & UART_FLAG_RXINV) {
+        dev(uart)->CTRLA.reg |= SERCOM_USART_CTRLA_TXINV;
+    }
+#endif
 
     /* calculate and set baudrate */
     uint32_t baud = (((sam0_gclk_freq(uart_config[uart].gclk_src) * 8) / baudrate) / 16);