diff --git a/makefiles/pseudomodules.inc.mk b/makefiles/pseudomodules.inc.mk
index 4f40cd2760..d6287c3f8e 100644
--- a/makefiles/pseudomodules.inc.mk
+++ b/makefiles/pseudomodules.inc.mk
@@ -86,6 +86,7 @@ PSEUDOMODULES += newlib_gnu_source
 PSEUDOMODULES += newlib_nano
 PSEUDOMODULES += openthread
 PSEUDOMODULES += picolibc
+PSEUDOMODULES += picolibc_stdout_buffered
 PSEUDOMODULES += pktqueue
 PSEUDOMODULES += posix_headers
 PSEUDOMODULES += printf_float
diff --git a/makefiles/stdio.inc.mk b/makefiles/stdio.inc.mk
index 4c7749d2f9..5c1d3bff22 100644
--- a/makefiles/stdio.inc.mk
+++ b/makefiles/stdio.inc.mk
@@ -55,3 +55,10 @@ ifneq (,$(filter stdio_semihosting,$(USEMODULE)))
   USEMODULE += xtimer
   FEATURES_REQUIRED += cpu_core_cortexm
 endif
+
+# enable stdout buffering for modules that benefit from sending out buffers in larger chunks
+ifneq (,$(filter picolibc,$(USEMODULE)))
+  ifneq (,$(filter stdio_cdc_acm stdio_ethos slipdev_stdio stdio_semihosting,$(USEMODULE)))
+    USEMODULE += picolibc_stdout_buffered
+  endif
+endif
diff --git a/sys/picolibc_syscalls_default/syscalls.c b/sys/picolibc_syscalls_default/syscalls.c
index 3f3d971bdd..060ef33c69 100644
--- a/sys/picolibc_syscalls_default/syscalls.c
+++ b/sys/picolibc_syscalls_default/syscalls.c
@@ -165,10 +165,12 @@ int kill(pid_t pid, int sig)
 
 #include "mutex.h"
 
-static mutex_t picolibc_put_mutex = MUTEX_INIT;
-
+#ifndef PICOLIBC_STDOUT_BUFSIZE
 #define PICOLIBC_STDOUT_BUFSIZE 64
+#endif
 
+#ifdef MODULE_PICOLIBC_STDOUT_BUFFERED
+static mutex_t picolibc_put_mutex = MUTEX_INIT;
 static char picolibc_stdout[PICOLIBC_STDOUT_BUFSIZE];
 static int picolibc_stdout_queued;
 
@@ -183,10 +185,14 @@ static void _picolibc_flush(void)
 static int picolibc_put(char c, FILE *file)
 {
     (void)file;
+
     mutex_lock(&picolibc_put_mutex);
     picolibc_stdout[picolibc_stdout_queued++] = c;
-    if (picolibc_stdout_queued == PICOLIBC_STDOUT_BUFSIZE || c == '\n')
+
+    if (picolibc_stdout_queued == PICOLIBC_STDOUT_BUFSIZE || c == '\n') {
         _picolibc_flush();
+    }
+
     mutex_unlock(&picolibc_put_mutex);
     return 1;
 }
@@ -200,6 +206,22 @@ static int picolibc_flush(FILE *file)
     return 0;
 }
 
+#else
+int picolibc_put(char c, FILE *file)
+{
+    (void)file;
+    stdio_write(&c, 1);
+    return 1;
+}
+
+static int picolibc_flush(FILE *file)
+{
+    (void)file;
+    return 0;
+}
+
+#endif
+
 static int picolibc_get(FILE *file)
 {
     (void)file;