diff --git a/examples/lorawan/Makefile b/examples/lorawan/Makefile
index 95e1e09b28..8265c73eee 100644
--- a/examples/lorawan/Makefile
+++ b/examples/lorawan/Makefile
@@ -17,7 +17,7 @@ APPKEY ?= 00000000000000000000000000000000
 DRIVER ?= sx1276
 
 # Default region is Europe and default band is 868MHz
-REGION ?= EU868
+LORA_REGION ?= EU868
 
 # Include the Semtech-loramac package
 USEPKG += semtech-loramac
@@ -26,9 +26,7 @@ USEMODULE += $(DRIVER)
 USEMODULE += fmt
 FEATURES_REQUIRED += periph_rtc
 
-CFLAGS += -DREGION_$(REGION)
 CFLAGS += -DDEVEUI=\"$(DEVEUI)\" -DAPPEUI=\"$(APPEUI)\" -DAPPKEY=\"$(APPKEY)\"
-CFLAGS += -DLORAMAC_ACTIVE_REGION=LORAMAC_REGION_$(REGION)
 
 # Comment this out to disable code in RIOT that does safety checking
 # which is not needed in a production environment but helps in the
diff --git a/examples/lorawan/README.md b/examples/lorawan/README.md
index f9e6f9679d..ef6401e2e9 100644
--- a/examples/lorawan/README.md
+++ b/examples/lorawan/README.md
@@ -18,12 +18,12 @@ Simply build and flash the application for a ST B-L072Z-LRWAN1 board:
 
     make flash term
 
-Use the `BOARD`, `DRIVER` and `REGION` make variables to adapt the application
+Use the `BOARD`, `DRIVER` and `LORA_REGION` make variables to adapt the application
 to your hardware setup and region of use:
 
 - `BOARD` can be one of the nucleo-64 boards
 - `DRIVER` can be either `sx1276` or `sx1272`
-- `REGION` can be `EU868`, `US915`, etc (see LoRaWAN regional parameters for
+- `LORA_REGION` can be `EU868`, `US915`, etc (see LoRaWAN regional parameters for
   details).
 
 ST Nucleo-64 can be used with mbed LoRa shields: there's one based on