diff --git a/pkg/lua/Makefile.dep b/pkg/lua/Makefile.dep
index 848218175b..74032e30ab 100644
--- a/pkg/lua/Makefile.dep
+++ b/pkg/lua/Makefile.dep
@@ -12,3 +12,8 @@ FEATURES_BLACKLIST += arch_mips32r2
 # (undefined reference to _times, _unlink and _link functions in provided
 # newlib nano).
 FEATURES_BLACKLIST += arch_riscv
+
+# LUA is not compatible with picolibc and raises errors at compile time:
+# - lua/liolib.c:671:38: error: '_IOFBF' undeclared (first use in this function)
+# - lua/liolib.c:671:46: error: '_IOLBF' undeclared (first use in this function)
+FEATURES_BLACKLIST += picolibc