diff --git a/sys/net/gnrc/netif/init_devs/auto_init_sx126x.c b/sys/net/gnrc/netif/init_devs/auto_init_sx126x.c
new file mode 100644
index 0000000000..b680a6848d
--- /dev/null
+++ b/sys/net/gnrc/netif/init_devs/auto_init_sx126x.c
@@ -0,0 +1,71 @@
+/*
+ * Copyright (C) 2021 Inria
+ *
+ * This file is subject to the terms and conditions of the GNU Lesser
+ * General Public License v2.1. See the file LICENSE in the top level
+ * directory for more details.
+ *
+ */
+
+/**
+ * @ingroup     sys_auto_init_gnrc_netif
+ * @{
+ *
+ * @file
+ * @brief       Auto initialization for SX1261/2 LoRa interfaces
+ *
+ * @author      Alexandre Abadie <alexandre.abadie@inria.fr>
+ */
+
+#include <assert.h>
+
+#include "log.h"
+#include "board.h"
+#include "net/gnrc/netif/lorawan_base.h"
+#include "net/gnrc/netif/raw.h"
+#include "net/gnrc.h"
+
+#include "sx126x.h"
+#include "sx126x_params.h"
+
+/**
+ * @brief   Calculate the number of configured SX126X devices
+ */
+#define SX126X_NUMOF                ARRAY_SIZE(sx126x_params)
+
+/**
+ * @brief   Define stack parameters for the MAC layer thread
+ */
+#define SX126X_STACKSIZE            (THREAD_STACKSIZE_DEFAULT)
+#ifndef SX126X_PRIO
+#define SX126X_PRIO                 (GNRC_NETIF_PRIO)
+#endif
+
+/**
+ * @brief   Allocate memory for device descriptors, stacks, and GNRC adaption
+ */
+static sx126x_t sx126x_devs[SX126X_NUMOF];
+static char sx126x_stacks[SX126X_NUMOF][SX126X_STACKSIZE];
+static gnrc_netif_t _netif[SX126X_NUMOF];
+
+void auto_init_sx126x(void)
+{
+    for (unsigned i = 0; i < SX126X_NUMOF; ++i) {
+        LOG_DEBUG("[auto_init_netif] initializing sx126x #%u\n", i);
+        sx126x_setup(&sx126x_devs[i], &sx126x_params[i], i);
+        if (IS_USED(MODULE_GNRC_NETIF_LORAWAN)) {
+            /* Currently only one lora device is supported */
+            assert(SX126X_NUMOF == 1);
+
+            gnrc_netif_lorawan_create(&_netif[i], sx126x_stacks[i],
+                                      SX126X_STACKSIZE, SX126X_PRIO,
+                                      "sx126x", (netdev_t *)&sx126x_devs[i]);
+        }
+        else {
+            gnrc_netif_raw_create(&_netif[i], sx126x_stacks[i],
+                                  SX126X_STACKSIZE, SX126X_PRIO,
+                                  "sx126x", (netdev_t *)&sx126x_devs[i]);
+        }
+    }
+}
+/** @} */
diff --git a/sys/net/gnrc/netif/init_devs/init.c b/sys/net/gnrc/netif/init_devs/init.c
index e164d6263c..f567120ac6 100644
--- a/sys/net/gnrc/netif/init_devs/init.c
+++ b/sys/net/gnrc/netif/init_devs/init.c
@@ -166,4 +166,9 @@ void gnrc_netif_init_devs(void)
         extern void auto_init_nrf802154(void);
         auto_init_nrf802154();
     }
+
+    if (IS_USED(MODULE_SX126X)) {
+        extern void auto_init_sx126x(void);
+        auto_init_sx126x();
+    }
 }