diff --git a/drivers/rn2xx3/rn2xx3.c b/drivers/rn2xx3/rn2xx3.c
index 4aaef94245..1a2fab6de6 100644
--- a/drivers/rn2xx3/rn2xx3.c
+++ b/drivers/rn2xx3/rn2xx3.c
@@ -252,7 +252,7 @@ int rn2xx3_mac_init(rn2xx3_t *dev)
     rn2xx3_mac_set_dr(dev, CONFIG_LORAMAC_DEFAULT_DR);
     rn2xx3_mac_set_tx_power(dev, CONFIG_LORAMAC_DEFAULT_TX_POWER);
     rn2xx3_mac_set_tx_port(dev, CONFIG_LORAMAC_DEFAULT_TX_PORT);
-    rn2xx3_mac_set_tx_mode(dev, LORAMAC_DEFAULT_TX_MODE);
+    rn2xx3_mac_set_tx_mode(dev, CONFIG_LORAMAC_DEFAULT_TX_MODE);
     rn2xx3_mac_set_adr(dev, LORAMAC_DEFAULT_ADR);
     rn2xx3_mac_set_retx(dev, LORAMAC_DEFAULT_RETX);
     rn2xx3_mac_set_linkchk_interval(dev, LORAMAC_DEFAULT_LINKCHK);
diff --git a/examples/gnrc_lorawan/Makefile b/examples/gnrc_lorawan/Makefile
index 81cc5cf47c..98d05a671e 100644
--- a/examples/gnrc_lorawan/Makefile
+++ b/examples/gnrc_lorawan/Makefile
@@ -47,7 +47,7 @@ CFLAGS += -DLORAMAC_DEFAULT_JOIN_PROCEDURE=LORAMAC_JOIN_OTAA
 #CFLAGS += -DCONFIG_LORAMAC_DEFAULT_DR=LORAMAC_DR_5
 
 # Set default messages to unconfirmable
-CFLAGS += -DLORAMAC_DEFAULT_TX_MODE=LORAMAC_TX_CNF
+CFLAGS += -DCONFIG_LORAMAC_DEFAULT_TX_MODE=LORAMAC_TX_UNCNF
 
 include $(RIOTBASE)/Makefile.include
 
diff --git a/pkg/semtech-loramac/contrib/semtech_loramac.c b/pkg/semtech-loramac/contrib/semtech_loramac.c
index 84aba663e3..92b6b4b4b0 100644
--- a/pkg/semtech-loramac/contrib/semtech_loramac.c
+++ b/pkg/semtech-loramac/contrib/semtech_loramac.c
@@ -381,7 +381,7 @@ void _init_loramac(semtech_loramac_t *mac,
     semtech_loramac_set_public_network(mac, LORAMAC_DEFAULT_PUBLIC_NETWORK);
     semtech_loramac_set_class(mac, CONFIG_LORAMAC_DEFAULT_DEVICE_CLASS);
     semtech_loramac_set_tx_port(mac, CONFIG_LORAMAC_DEFAULT_TX_PORT);
-    semtech_loramac_set_tx_mode(mac, LORAMAC_DEFAULT_TX_MODE);
+    semtech_loramac_set_tx_mode(mac, CONFIG_LORAMAC_DEFAULT_TX_MODE);
     semtech_loramac_set_system_max_rx_error(mac,
                                             LORAMAC_DEFAULT_SYSTEM_MAX_RX_ERROR);
     semtech_loramac_set_min_rx_symbols(mac, LORAMAC_DEFAULT_MIN_RX_SYMBOLS);
diff --git a/sys/include/net/loramac.h b/sys/include/net/loramac.h
index 9254c7b630..b81e9dc962 100644
--- a/sys/include/net/loramac.h
+++ b/sys/include/net/loramac.h
@@ -246,9 +246,15 @@ extern "C" {
 /**
  * @brief   Default MAC TX mode (confirmable or unconfirmable)
  */
- #ifndef LORAMAC_DEFAULT_TX_MODE
- #define LORAMAC_DEFAULT_TX_MODE               (LORAMAC_TX_CNF)
- #endif
+#if IS_ACTIVE(CONFIG_LORAMAC_DEFAULT_TX_MODE_CNF)
+#define CONFIG_LORAMAC_DEFAULT_TX_MODE          (LORAMAC_TX_CNF)
+#elif IS_ACTIVE(CONFIG_LORAMAC_DEFAULT_TX_MODE_UNCNF)
+#define CONFIG_LORAMAC_DEFAULT_TX_MODE          (LORAMAC_TX_UNCNF)
+#endif
+
+#ifndef CONFIG_LORAMAC_DEFAULT_TX_MODE
+#define CONFIG_LORAMAC_DEFAULT_TX_MODE          (LORAMAC_TX_CNF)
+#endif
 
 /**
  * @brief   Default adaptive datarate state
diff --git a/sys/net/gnrc/netif/lorawan/gnrc_netif_lorawan.c b/sys/net/gnrc/netif/lorawan/gnrc_netif_lorawan.c
index c1542631fa..efe7bfdd52 100644
--- a/sys/net/gnrc/netif/lorawan/gnrc_netif_lorawan.c
+++ b/sys/net/gnrc/netif/lorawan/gnrc_netif_lorawan.c
@@ -183,7 +183,7 @@ static void _reset(gnrc_netif_t *netif)
     netif->lorawan.demod_margin = 0;
     netif->lorawan.num_gateways = 0;
     netif->lorawan.port = CONFIG_LORAMAC_DEFAULT_TX_PORT;
-    netif->lorawan.ack_req = LORAMAC_DEFAULT_TX_MODE == LORAMAC_TX_CNF;
+    netif->lorawan.ack_req = CONFIG_LORAMAC_DEFAULT_TX_MODE == LORAMAC_TX_CNF;
     netif->lorawan.flags = 0;
 }
 
diff --git a/sys/shell/commands/sc_loramac.c b/sys/shell/commands/sc_loramac.c
index 1d494f7237..72cd487f41 100644
--- a/sys/shell/commands/sc_loramac.c
+++ b/sys/shell/commands/sc_loramac.c
@@ -397,7 +397,7 @@ int _loramac_handler(int argc, char **argv)
             return 1;
         }
 
-        uint8_t cnf = LORAMAC_DEFAULT_TX_MODE;  /* Default: confirmable */
+        uint8_t cnf = CONFIG_LORAMAC_DEFAULT_TX_MODE;  /* Default: confirmable */
         uint8_t port = CONFIG_LORAMAC_DEFAULT_TX_PORT; /* Default: 2 */
         /* handle optional parameters */
         if (argc > 3) {