diff --git a/pkg/nanopb/Makefile b/pkg/nanopb/Makefile
index f31c7d5569..7f7dff0101 100644
--- a/pkg/nanopb/Makefile
+++ b/pkg/nanopb/Makefile
@@ -1,6 +1,6 @@
 PKG_NAME=nanopb
 PKG_URL=https://github.com/nanopb/nanopb
-PKG_VERSION=3eb9a75c1e66e6182e87e2bd758ff2a4d16acbdc # nanopb-0.4.1
+PKG_VERSION=1466e6f953835b191a7f5acf0c06c941d4cd33d9 # nanopb-0.4.3
 PKG_LICENSE=MIT
 
 include $(RIOTBASE)/pkg/pkg.mk
diff --git a/pkg/nanopb/patches/0001-generator-nanopb_generator.py-use-python3.patch b/pkg/nanopb/patches/0001-generator-nanopb_generator.py-use-python3.patch
deleted file mode 100644
index db6b4f63d3..0000000000
--- a/pkg/nanopb/patches/0001-generator-nanopb_generator.py-use-python3.patch
+++ /dev/null
@@ -1,22 +0,0 @@
-From 416436502170cfd77d19c6e967cc79267b4513d6 Mon Sep 17 00:00:00 2001
-From: Kaspar Schleiser <kaspar@schleiser.de>
-Date: Sat, 12 Oct 2019 00:26:19 +0200
-Subject: [PATCH] generator/nanopb_generator.py: use python3
-
----
- generator/nanopb_generator.py | 2 +-
- 1 file changed, 1 insertion(+), 1 deletion(-)
-
-diff --git a/generator/nanopb_generator.py b/generator/nanopb_generator.py
-index 03f41a0..4f0ab47 100755
---- a/generator/nanopb_generator.py
-+++ b/generator/nanopb_generator.py
-@@ -1,4 +1,4 @@
--#!/usr/bin/env python
-+#!/usr/bin/env python3
- # kate: replace-tabs on; indent-width 4;
- 
- from __future__ import unicode_literals
--- 
-2.23.0
-